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伤寒沙门菌在抗菌治疗期间对可传播耐药性的体内选择

In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy.

作者信息

Schwalbe R S, Hoge C W, Morris J G, O'Hanlon P N, Crawford R A, Gilligan P H

机构信息

Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.

出版信息

Antimicrob Agents Chemother. 1990 Jan;34(1):161-3. doi: 10.1128/AAC.34.1.161.

DOI:10.1128/AAC.34.1.161
PMID:2327754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171541/
Abstract

We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.

摘要

我们报告了一株伤寒沙门氏菌在接受多次抗生素治疗后获得了对氨苄西林、氯霉素、甲氧苄啶-磺胺甲恶唑和庆大霉素的耐药性。从同一粪便样本中分离出的大肠杆菌和肺炎克雷伯菌菌株呈现出相同的耐药模式。琼脂糖凝胶电泳显示，伤寒沙门氏菌和实验室衍生的转接合子含有存在于耐药肠道细菌中的高分子量质粒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/580e/171541/cfa7a8f12180/aac00057-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/580e/171541/009cec1674b4/aac00057-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/580e/171541/cfa7a8f12180/aac00057-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/580e/171541/009cec1674b4/aac00057-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/580e/171541/cfa7a8f12180/aac00057-0194-b.jpg

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