环丙沙星不抑制线粒体功能，但其他抗生素会。
Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do.
作者信息
Riesbeck K, Bredberg A, Forsgren A
机构信息
Department of Medical Microbiology, University of Lund, Malmö General Hospital, Sweden.
出版信息
Antimicrob Agents Chemother. 1990 Jan;34(1):167-9. doi: 10.1128/AAC.34.1.167.
Abstract
At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not.
摘要
在临床浓度下，环丙沙星不抑制线粒体DNA复制、氧化磷酸化、蛋白质合成或线粒体质量（跨膜电位）。未观察到DNA超螺旋形式的差异。四环素和氯霉素在临床可达到的浓度下抑制蛋白质合成，而利福平、夫西地酸和克林霉素则无此作用。
相似文献
1
Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do.
Antimicrob Agents Chemother. 1990 Jan;34(1):167-9. doi: 10.1128/AAC.34.1.167.
2
In vitro effects of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation in rats liver mitochondria.
Biochem Pharmacol. 1977 Nov 15;26(22):2101-6. doi: 10.1016/0006-2952(77)90258-1.
3
The in vitro effects of tannic acid on rat liver mitochondrial respiration and oxidative phosphorylation.
Chem Pharm Bull (Tokyo). 1987 Mar;35(3):1176-82. doi: 10.1248/cpb.35.1176.
4
Dual inhibitory effects of the peptide antibiotics leucinostatins on oxidative phosphorylation in mitochondria.
Cell Struct Funct. 1990 Feb;15(1):53-8. doi: 10.1247/csf.15.53.
5
The effect of two new peptide antibiotics, the hypelcins, on mitochondrial function.
Experientia. 1980 May 15;36(5):550-2. doi: 10.1007/BF01965794.
6
Differential effects of chloramphenicol and its nitrosoanalogue on protein synthesis and oxidative phosphorylation in rat liver mitochondria.
Biochem Pharmacol. 1980 Oct 1;29(19):2605-9. doi: 10.1016/0006-2952(80)90074-x.
7
Effects of ticlopidine, a new platelet antiaggregating agent, and its analogues on mitochondrial metabolism. Oxidative phosphorylation, protein synthesis and DNA polymerase activity.
Biochem Pharmacol. 1984 Dec 1;33(23):3893-8. doi: 10.1016/0006-2952(84)90057-1.
8
[Effect of heliomycin on the respiration and oxidative phosphorylation of the liver mitochondria of the rat].
Antibiotiki. 1983 Mar;28(3):192-4.
9
Detection of a phosphorylated intermediate in mitochondrial oxidative phosphorylation.
Biochem Biophys Res Commun. 1970 Sep 10;40(5):1155-61. doi: 10.1016/0006-291x(70)90915-0.
10
Uncoupling action of polychlorinated biphenyls (Kanechlor-400) on oxidative phosphorylation in rat liver mitochondria.
Arch Environ Contam Toxicol. 1984 Mar;13(2):225-9. doi: 10.1007/BF01055880.
引用本文的文献
1
Immune modulatory effects of tulathromycin, gamithromycin, and oxytetracycline in cattle.
BMC Vet Res. 2024 Oct 9;20(1):456. doi: 10.1186/s12917-024-04254-x.
2
Activation of the integrated stress response is a vulnerability for multidrug-resistant FBXW7-deficient cells.
EMBO Mol Med. 2022 Sep 7;14(9):e15855. doi: 10.15252/emmm.202215855. Epub 2022 Jul 21.
3
Tetracyclines-An Important Therapeutic Tool for Dermatologists.
Int J Environ Res Public Health. 2022 Jun 13;19(12):7246. doi: 10.3390/ijerph19127246.
4
Development of a Plasmid Shuttle Vector System for Genetic Manipulation of Chlamydia psittaci.
mSphere. 2020 Aug 26;5(4):e00787-20. doi: 10.1128/mSphere.00787-20.
5
High-throughput screening of clinically approved drugs that prime nonviral gene delivery to human Mesenchymal stem cells.
J Biol Eng. 2020 May 19;14:16. doi: 10.1186/s13036-020-00238-1. eCollection 2020.
6
Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine.
Sci Rep. 2020 Mar 9;10(1):4363. doi: 10.1038/s41598-020-61381-9.
7
A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.
J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
8
The adverse effect of gentamicin on cell metabolism in three cultured mammary cell lines: "Are cell culture data skewed?".
PLoS One. 2019 Apr 1;14(4):e0214586. doi: 10.1371/journal.pone.0214586. eCollection 2019.
9
Impacts of Antibiotic and Bacteriophage Treatments on the Gut-Symbiont-Associated Blissus insularis (Hemiptera: Blissidae).
Insects. 2016 Nov 3;7(4):61. doi: 10.3390/insects7040061.
10
The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans.
mSphere. 2016 Jan 13;1(1). doi: 10.1128/mSphere.00080-15. eCollection 2016 Jan-Feb.
本文引用的文献
1
On the evolutionary origin of the plant mitochondrion and its genome.
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2267-71. doi: 10.1073/pnas.86.7.2267.
2
A procedure for the rapid preparation of mitochondria from rat liver.
Biochem J. 1982 Jun 15;204(3):731-5. doi: 10.1042/bj2040731.
3
Interaction of rhodamine 123 with living cells studied by flow cytometry.
Cancer Res. 1982 Mar;42(3):799-806.
4
Antibiotic-host defence interactions in vitro and in vivo.
Scand J Infect Dis Suppl. 1980;Suppl 24:195-203.
5
Probing mitochondria in living cells with rhodamine 123.
Cold Spring Harb Symp Quant Biol. 1982;46 Pt 1:141-55. doi: 10.1101/sqb.1982.046.01.018.
6
Amino acid incorporation by isolated rat liver mitochondria into two protein components of mitochondrial ATPase complex. Lack of incorporation into dicyclohexylcarbodiimide binding proteolipid.
FEBS Lett. 1980 Jun 2;114(2):197-201. doi: 10.1016/0014-5793(80)81113-6.
7
Antibacterial drugs and their interference with the biogenesis of mitochondria in animal and human cells.
Pharm Weekbl Sci. 1983 Jun 24;5(3):81-7. doi: 10.1007/BF01960982.
8
The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria.
Biochim Biophys Acta. 1983 Sep 9;740(4):417-27. doi: 10.1016/0167-4781(83)90090-8.
9
Intraphagocytic bactericidal activity of bacterial DNA gyrase inhibitors against Serratia marcescens.
Chemotherapy. 1984;30(6):379-86. doi: 10.1159/000238297.
10
Deoxyribonucleic acid biosynthesis in mitochondria. Studies on the incorporation of labeled precursors into mitochondrial deoxyribonucleic acid.
J Biol Chem. 1973 Mar 25;248(6):1912-9.
Zotero 插件