脆弱拟杆菌群分离株的体外抗菌谱比较：由于药敏试验方法的差异，两个机构的耐药率有所不同。
Comparison of in vitro antibiograms of Bacteroides fragilis group isolates: differences in resistance rates in two institutions because of differences in susceptibility testing methodology.
作者信息
Aldridge K E, Wexler H M, Sanders C V, Finegold S M
机构信息
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
出版信息
Antimicrob Agents Chemother. 1990 Jan;34(1):179-81. doi: 10.1128/AAC.34.1.179.
Abstract
With 120 clinical isolates of the Bacteroides fragilis group, a comparison of rates of resistance to selected antimicrobial agents by using two susceptibility tests was performed in two medical institutions. The broth microdilution method produced MICs significantly lower than those determined by the agar dilution method. With ceftizoxime and cefoxitin, 88 and 18%, respectively, of the MICs were greater than or equal to 2 twofold dilutions apart. These differences in MIC results produced major interpretive discrepancies for ceftizoxime and cefoxitin, whereas no significant differences in resistance rates were noted for clindamycin and metronidazole.
摘要
在两家医疗机构中，对120株脆弱拟杆菌属临床分离株，运用两种药敏试验方法比较了对选定抗菌药物的耐药率。肉汤微量稀释法得出的最低抑菌浓度（MIC）显著低于琼脂稀释法测定的结果。对于头孢唑肟和头孢西丁，分别有88%和18%的MIC相差大于或等于2倍稀释度。这些MIC结果的差异导致头孢唑肟和头孢西丁在主要解释上出现差异，而对于克林霉素和甲硝唑，未观察到耐药率有显著差异。
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