每周氟康唑治疗复发性外阴阴道念珠菌病：系统评价和荟萃分析。
Weekly fluconazole therapy for recurrent vulvovaginal candidiasis: a systematic review and meta-analysis.
机构信息
Laboratory of Epidemiology University of Extremo Sul Catarinense, Criciúma, SC, Brazil.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2013 Apr;167(2):132-6. doi: 10.1016/j.ejogrb.2012.12.001. Epub 2012 Dec 29.
OBJECTIVE
To investigate the efficacy, compared to placebo, of fluconazole 150 mg weekly, given for six months as prophylaxis against recurrent vulvovaginal candidiasis (RVVC).
STUDY DESIGN
A quantitative systematic review was performed, and randomized controlled trials were included. We conducted searches at Medline, EMBASE, Lilacs, Cochrane Library and ICI Web of Science from 1980 to March 2012. We used the odds ratio (OR) with confidence intervals (CI) of 95% using a random effects model of Mantel-Haenszel. The software used was Review Manager version 5.0.
RESULTS
Through the search strategies we identified 249 articles, of which only two were part of the meta-analysis. Fluconazole was more effective than placebo in reducing symptomatic episodes of VVC, immediately after treatment (OR 0.10, 95% CI 0.03-0.34), 3 months after treatment (OR 0.23, 95% CI 0.07-0.74) and 6 months after treatment (OR 0.39, 95% CI 0.24-0.64).
CONCLUSION
Weekly treatment with fluconazole (150 mg) for six months is effective against RVVC.
目的
研究氟康唑 150 毫克每周一次，连续六个月预防复发性外阴阴道念珠菌病（RVVC）的疗效，与安慰剂相比。
研究设计
进行了定量系统评价，并纳入了随机对照试验。我们从 1980 年到 2012 年 3 月在 Medline、EMBASE、Lilacs、Cochrane 图书馆和 ICI Web of Science 进行了检索。我们使用 Mantel-Haenszel 的随机效应模型，使用 95%置信区间的比值比（OR）进行分析。使用的软件是 Review Manager 版本 5.0。
结果
通过搜索策略，我们确定了 249 篇文章，其中只有两篇是荟萃分析的一部分。氟康唑在治疗后即刻（OR 0.10，95%CI 0.03-0.34）、治疗后 3 个月（OR 0.23，95%CI 0.07-0.74）和治疗后 6 个月（OR 0.39，95%CI 0.24-0.64）时，与安慰剂相比，更能有效减少 VVC 的症状发作。
结论
每周用氟康唑（150 毫克）治疗六个月对 RVVC 有效。
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