Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Japan.
Adv Drug Deliv Rev. 2013 Jan;65(1):139-47. doi: 10.1016/j.addr.2012.11.006. Epub 2012 Dec 29.
Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be related to physicochemical properties of the delivery system. Various delivery systems including macromolecular drug conjugates, chemically or genetically modified proteins, and particulate drug carriers have been designed and developed so far. In this article, we review physiological and pharmacokinetic implications of the delivery systems.
药物传递系统涉及旨在通过控制药物的生物分布来最大化药物疗效的技术。为了优化传递系统的功能，应该系统地了解其生物分布特征。基于清除概念的药代动力学分析提供了生物分布的定量信息，该信息可以与传递系统的物理化学性质相关。迄今为止，已经设计和开发了各种传递系统，包括大分子药物偶联物、化学或基因修饰的蛋白质和颗粒药物载体。在本文中，我们回顾了传递系统的生理和药代动力学意义。
