VU University Amsterdam, Department of Biological Psychology, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.
J Pers Disord. 2012 Dec;26(6):867-79. doi: 10.1521/pedi.2012.26.6.867.
Borderline personality disorder (BPD) and substance use disorders often co-occur. Both disorders are heritable and family studies showed that there are familial factors that increase the risk for BPD as well as substance use/abuse. This is the first study that investigates whether the association of borderline personality traits (BPT) with substance use reflects an underlying genetic vulnerability or nongenetic familial influences. To this end we analyzed data of 5,638 Dutch and Belgian twins aged between 21-50 years from 3,567 families. Significant associations between BPT and high alcohol consumption (r = .192), regular smoking (r = .299), and ever use of cannabis (r = .254) were found. Bivariate genetic analyses showed that the associations of BPT and substance use had different etiologies. For regular smoking and for ever use of cannabis, the correlation with BPT was explained by common genetic factors. Interestingly, for high alcohol consumption and BPT the association was explained by unique environmental factors that influence both traits rather than common genetic factors.
边缘型人格障碍（BPD）和物质使用障碍常同时发生。这两种疾病都具有遗传性，家族研究表明，存在一些家族因素会增加 BPD 和物质使用/滥用的风险。这是第一项研究，旨在调查边缘型人格特质（BPT）与物质使用之间的关联是否反映了潜在的遗传脆弱性或非遗传的家族影响。为此，我们分析了来自 3567 个家庭的 5638 名年龄在 21-50 岁的荷兰和比利时双胞胎的数据。BPT 与高酒精消费（r =.192）、定期吸烟（r =.299）和大麻使用史（r =.254）之间存在显著关联。双变量遗传分析表明，BPT 和物质使用之间的关联具有不同的病因。对于定期吸烟和大麻使用，BPT 与物质使用之间的相关性由共同的遗传因素解释。有趣的是，对于高酒精消费和 BPT，与这两个特征相关的关联是由影响两者的独特环境因素而不是共同的遗传因素解释的。
