Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, India.
Nutr Rev. 2013 Jan;71(1):23-34. doi: 10.1111/j.1753-4887.2012.00542.x. Epub 2012 Nov 9.
Dietary interventions for preventing colon cancer have recently attracted increased attention from researchers and clinicians. The probiotics have emerged as potential therapeutic agents but are also regarded as healthy dietary supplements for nutrition and health applications. The probiotic metabolome may interfere with various cellular and molecular processes, including the onset and progression of colon cancer. Probiotic metabolites may lead to the modulation of diverse cellular signal transduction and metabolic pathways. The gut microbial metabolites (organic acids, bacteriocins, peptides, etc.) have been noted to interact with multiple key targets in various metabolic pathways that regulate cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, and metastasis. Progress in this field suggests that epigenetic alterations will be widely used in the near future to manage colon cancer. The present review provides insights into the molecular basis of the therapeutic applications and the chemopreventive activities of certain probiotic metabolites, with emphasis on the interaction between these metabolites and the molecular signaling cascades that are considered to be epigenetic targets in preventing colon cancer.
近年来，饮食干预预防结肠癌引起了研究人员和临床医生的极大关注。益生菌已成为潜在的治疗剂，但也被视为营养和健康应用的健康饮食补充剂。益生菌代谢组可能会干扰多种细胞和分子过程，包括结肠癌的发生和进展。益生菌代谢物可能导致不同细胞信号转导和代谢途径的调节。肠道微生物代谢物（有机酸、细菌素、肽等）已被注意到与调节细胞增殖、分化、凋亡、炎症、血管生成和转移的各种代谢途径中的多个关键靶标相互作用。该领域的进展表明，表观遗传改变将在不久的将来被广泛用于管理结肠癌。本综述提供了对某些益生菌代谢物的治疗应用和化学预防活性的分子基础的深入了解，重点介绍了这些代谢物与被认为是预防结肠癌的表观遗传靶标的分子信号级联之间的相互作用。
