Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA.
Curr Top Dev Biol. 2013;102:385-421. doi: 10.1016/B978-0-12-416024-8.00014-3.
To succeed in fertilization, spermatozoa must decode environmental cues which require a set of ion channels. Recent findings have revealed that K(+) and Cl(-) channels participate in some of the main sperm functions. This work reviews the evidence indicating the involvement of K(+) and Cl(-) channels in motility, maturation, and the acrosome reaction, and the advancement in identifying their molecular identity and modes of regulation. Improving our insight on how these channels operate will strengthen our ability to surmount some infertility problems, improve animal breeding, preserve biodiversity, and develop selective and secure male contraceptives.
为了成功受精,精子必须解码环境线索,这需要一组离子通道。最近的研究发现,K(+)和 Cl(-)通道参与了一些主要的精子功能。本文综述了 K(+)和 Cl(-)通道在运动、成熟和顶体反应中的作用的证据,并介绍了鉴定其分子特性和调节方式的进展。提高我们对这些通道如何运作的认识将增强我们克服一些不孕问题、改善动物繁殖、保护生物多样性和开发选择性和安全的男性避孕药的能力。