Uludag University Medical Faculty, Bursa, Turkey.
Respir Med. 2012 Dec;106 Suppl 2:S45-59. doi: 10.1016/S0954-6111(12)70014-8.
COPD is a progressive pulmonary disease which may have a profound impact on general health status and quality of life. This article presents data on the burden of COPD obtained from the BREATHE study in the Middle East, North Africa and Pakistan. This study was a large general population survey of COPD conducted in eleven countries of the region using a standardised methodology. A total of 62,086 subjects were screened, of whom 2,187 fulfilled the "epidemiological" definition of COPD. Data on symptoms, perceived disease severity, impact on work, limitations in activities and psychological distress were collected. 1,392 subjects were analysable of whom 661 (47.5%) reported experiencing an exacerbation of their respiratory condition, 49.4% reported comorbidities and 5.5% reported severe breathlessness as measured with the MRC breathlessness questionnaire. The degree of breathlessness, as well as the perceived severity, was correlated with the overall disease impact as measured with the COPD Assessment Test (p < 0.001). 374 subjects (28.4%) reported that their respiratory condition prevented them from working and this proportion rose to 47.8% in subjects who perceived their respiratory condition as severe. 47.9% of subjects reported difficulties in normal physical exertion, 37.5% in social activities and 31.7% in family activities. Psychological distress was reported by between 42.3% and 53.2% of subjects, depending on the item. In conclusion, the burden of COPD is important, and covers central aspects of daily life. For this reason, physicians should take time to discuss it with their patients, and ensure that the management strategy proposed addresses all their needs.
COPD 是一种进行性肺部疾病，可能对整体健康状况和生活质量产生深远影响。本文介绍了从中东、北非和巴基斯坦的 BREATHE 研究中获得的 COPD 负担数据。这项研究是在该地区 11 个国家进行的一项 COPD 大型普通人群调查，采用了标准化方法。共对 62,086 名受试者进行了筛查，其中 2,187 名符合 COPD 的“流行病学”定义。收集了症状、感知疾病严重程度、对工作的影响、活动受限和心理困扰的数据。对 1,392 名受试者进行了分析，其中 661 名（47.5%）报告他们的呼吸状况恶化，49.4%报告合并症，5.5%报告呼吸困难（采用 MRC 呼吸困难问卷测量）严重。呼吸困难的程度以及感知的严重程度与 COPD 评估测试（COPD Assessment Test，CAT）测量的整体疾病影响相关（p < 0.001）。374 名受试者（28.4%）报告他们的呼吸状况使他们无法工作，而在认为自己的呼吸状况严重的受试者中，这一比例上升到 47.8%。47.9%的受试者报告在正常体力活动中存在困难，37.5%在社会活动中，31.7%在家庭活动中存在困难。根据不同的项目，42.3%至 53.2%的受试者报告存在心理困扰。总之，COPD 的负担很重要，涵盖了日常生活的核心方面。因此，医生应该花时间与患者讨论这个问题，并确保提出的管理策略满足他们的所有需求。
