Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, 188 Raja S. C. Mullick Road, Kolkata 700 032, India.
Food Chem Toxicol. 2013 May;55:78-91. doi: 10.1016/j.fct.2012.12.040. Epub 2013 Jan 2.
Lead (Pb) is considered to be a multi-target toxicant. The present study was undertaken to evaluate the protective effect of aqueous extract of Corchorus olitorius leaves against Pb-acetate induced toxic manifestation in blood, liver, kidney, brain and heart of Wistar rats. The Pb-acetate (5mg/kg body weight) treated rats exhibited a significant inhibition of co-enzymes Q, antioxidant enzymes and reduced glutathione levels in the tissues. In addition, the extent of lipid peroxidation, DNA fragmentation and haematological parameters were significantly altered in the Pb-acetate treated rats as compared to control. Simultaneous administration of test extract (25, 50 and 100mg/kg body weight), could significantly restore the biochemical and haematological parameters near to the normal status through antioxidant activity and/or by preventing bioaccumulation of Pb within the tissues of experimental rats. Presence of substantial quantity of phenolics and flavonoids in the extract may be responsible for the observed protective role against Pb-intoxication.
铅（Pb）被认为是一种多靶点毒物。本研究旨在评估蕹菜叶水提物对醋酸铅诱导的 Wistar 大鼠血液、肝脏、肾脏、大脑和心脏毒性表现的保护作用。醋酸铅（5mg/kg 体重）处理的大鼠组织中辅酶 Q、抗氧化酶和还原型谷胱甘肽水平显著抑制。此外，与对照组相比，醋酸铅处理的大鼠的脂质过氧化、DNA 片段化和血液学参数显著改变。同时给予试验提取物（25、50 和 100mg/kg 体重），通过抗氧化活性和/或防止 Pb 在实验大鼠组织内的生物蓄积，可以显著将生化和血液学参数恢复到接近正常状态。提取物中存在大量的酚类和类黄酮可能是其对 Pb 中毒观察到的保护作用的原因。
