let-7 及其靶标癌基因的调控（综述）
Regulation of let-7 and its target oncogenes (Review).
作者信息
Wang Xirui, Cao Lei, Wang Yingyi, Wang Xiefeng, Liu Ning, You Yongping
机构信息
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
出版信息
Oncol Lett. 2012 May;3(5):955-960. doi: 10.3892/ol.2012.609. Epub 2012 Feb 14.
Abstract
MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of gene expression in cells. Several novel factors and feedback loops involved in the regulation of the synthesis of let-7 have been identified and additional let-7 target genes have been found. Let-7 has also been shown to be significantly correlated with the occurrence and development of cancer and the results of preliminary studies suggest that it is involved in the regulation of oncogenic pathways in numerous types of tumors. Let-7 is, therefore, a potential molecular target for tumor therapy. Thus, this review examined let-7 and the correlation between let-7 and oncogenic pathways in cancer.
摘要
微小RNA（miRNA）是高度进化保守的非编码小RNA，最初在秀丽隐杆线虫中被发现。Let-7 miRNA参与细胞中基因表达的调控。已经鉴定出几个参与Let-7合成调控的新因子和反馈环，并且发现了更多Let-7靶基因。Let-7也已被证明与癌症的发生和发展显著相关，初步研究结果表明它参与多种肿瘤致癌途径的调控。因此，Let-7是肿瘤治疗的潜在分子靶点。因此，本综述研究了Let-7以及Let-7与癌症致癌途径之间的相关性。
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