Department of Surgery, University of Lübeck, Lübeck, Germany.
Langenbecks Arch Surg. 2013 Feb;398(2):251-8. doi: 10.1007/s00423-012-1043-4. Epub 2013 Jan 8.
Research projects and clinical trials strongly rely on high-quality biospecimens which are provided by biobanks. Since differences in sample processing and storage can strongly affect the outcome of such studies, standardization between biobanks is necessary to guarantee reliable results of large, multicenter studies. The German Cancer Aid Foundation (Deutsche Krebshilfe e.V.) has therefore initiated the priority program "tumor tissue banks" in 2010 by funding four biobank networks focusing on central nervous system tumors, melanomas, breast carcinomas, and colorectal carcinomas. The latter one, the North German Tumor Bank of Colorectal Cancer (ColoNet) is managed by surgeons, pathologists, gastroenterologists, oncologists, scientists, and medical computer scientists.
The ColoNet consortium has developed and harmonized standard operating procedures concerning all biobanking aspects. Crucial steps for quality assurance have been implemented and resulted in certification according to DIN EN ISO 9001. A further achievement is the construction of a web-based database for exploring available samples. In addition, common scientific projects have been initiated. Thus, ColoNet's repository will be used for research projects in order to improve early diagnosis, therapy, follow-up, and prognosis of colorectal cancer patients. Apart from the routine sample storage at -170 °C, the tumor banks' unique characteristic is the participation of outpatient clinics and private practices to further expand the sample and clinical data collection.
The first 2 years of funding by the German Cancer Aid Foundation have already led to a closer scientific connection between the participating institutions and to a substantial collection of biospecimens obtained under highly standardized conditions.
研究项目和临床试验强烈依赖于高质量的生物样本，这些样本由生物库提供。由于样本处理和储存的差异会强烈影响此类研究的结果，因此生物库之间需要标准化，以保证大型多中心研究的可靠结果。德国癌症援助基金会（Deutsche Krebshilfe e.V.）因此于 2010 年启动了“肿瘤组织库”优先计划，资助了四个专注于中枢神经系统肿瘤、黑色素瘤、乳腺癌和结直肠癌的生物库网络。其中，结直肠癌北德肿瘤库（ColoNet）由外科医生、病理学家、胃肠病学家、肿瘤学家、科学家和医学计算机科学家管理。
ColoNet 联盟已经制定并协调了所有生物库方面的标准操作程序。已经实施了保证质量的关键步骤，并根据 DIN EN ISO 9001 进行了认证。另一个成就是构建了一个基于网络的数据库，用于探索可用样本。此外，还启动了共同的科学项目。因此，ColoNet 的存储库将用于研究项目，以改善结直肠癌患者的早期诊断、治疗、随访和预后。除了在-170°C 下常规储存样本外，肿瘤库的独特特征是参与门诊和私人诊所，以进一步扩大样本和临床数据的收集。
德国癌症援助基金会资助的头两年已经导致参与机构之间更紧密的科学联系，并在高度标准化的条件下收集了大量的生物样本。
