Feng Shuyi, Lin Saizheng, Ma Lingling, Xu Song, Chen Yan
The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Department of Gastroenterology, Ningbo Zhenhai People's Hospital, Ningbo, Zhejiang Province, People's Republic of China.
Patient Prefer Adherence. 2020 Aug 24;14:1513-1521. doi: 10.2147/PPA.S265346. eCollection 2020.
Inflammatory bowel disease (IBD) patients are at risk for HBV and varicella, which makes vaccination an important role.
To assess knowledge and vaccination rate of Chinese IBD patients and find the influencing factors.
An online anonymous questionnaire was distributed to IBD patients through www.wjx.cn in the People's Republic of China during October 2019 to February 2020. The Kappa value and multivariate analysis were used to analyze the data using SPSS 25.0.
Among 900 participants, 746 (82.9%) hadreceived immunosuppressive treatment. Only 25 (2.78%) patients thought that they had sufficient information on vaccination, and 311 (34.6%) patients remembered being reminded about vaccination by their doctors before. The self-reported vaccination rate for hepatitis B was 125/666 (18.8%), and for varicella 44/671 (6.6%). Information from doctors was positively associated with vaccination status of hepatitis B (odds ratio [OR]=4.61, 95% confidence interval [Cl: 2.73-7.76], <0.001) and varicella (OR=4.93, 95%Cl :2.02-12.05, <0.001). The patients whose duration of IBD diagnosis was more than 2 years (OR=0.37, 95% Cl: 0.16-0.87, =0.022) and those older than 38 years (OR=0.37, 95% Cl: 0.14-1.00, =0.0497) were negatively related with the status of varicella vaccination.
Vaccination-related knowledge level in IBD patients appeared to be low and the rate of vaccination of both hepatitis and varicella was way below the recommended level. Proper education of both IBD patients and gastroenterologists in the People's Republic of China is needed.
炎症性肠病（IBD）患者有感染乙肝病毒和水痘的风险，这使得疫苗接种至关重要。
评估中国IBD患者的疫苗接种知识和接种率，并找出影响因素。
2019年10月至2020年2月期间，通过问卷星（www.wjx.cn）向中国的IBD患者发放在线匿名问卷。使用SPSS 25.0软件进行Kappa值分析和多因素分析。
在900名参与者中，746名（82.9%）接受过免疫抑制治疗。只有25名（2.78%）患者认为自己对疫苗接种有足够的了解，311名（34.6%）患者记得医生曾提醒过他们接种疫苗。乙肝疫苗的自我报告接种率为125/666（18.8%），水痘疫苗为44/671（6.6%）。医生提供的信息与乙肝疫苗接种状况呈正相关（比值比[OR]=4.61，95%置信区间[CI：2.73 - 7.76]，<0.001），与水痘疫苗接种状况也呈正相关（OR=4.93，95%CI：2.02 - 12.05，<0.001）。IBD诊断时长超过2年的患者（OR=0.37，95%CI：0.16 - 0.87，=0.022）和年龄大于38岁的患者（OR=0.37，95%CI：0.14 - 1.00，=0.0497）与水痘疫苗接种状况呈负相关。
IBD患者的疫苗接种相关知识水平似乎较低，乙肝和水痘疫苗接种率远低于推荐水平。中国需要对IBD患者和胃肠病学家进行适当的教育。
