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重测序水稻基因组:水稻基因组学的崭新时代。

Resequencing rice genomes: an emerging new era of rice genomics.

机构信息

National Center for Gene Research, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200233, China.

出版信息

Trends Genet. 2013 Apr;29(4):225-32. doi: 10.1016/j.tig.2012.12.001. Epub 2013 Jan 4.

Abstract

Rice is a model system for crop genomics studies. Much of the early work on rice genomics focused on analyzing genome-wide genetic variation to further understand rice gene functions in agronomic traits and to generate data and resources for rice research. The advent of next-generation high-throughput DNA sequencing technologies and the completion of high-quality reference genome sequences have enabled the development of sequencing-based genotyping and genome-wide association studies (GWAS) that have significantly advanced rice genetics research. This has led to the emergence of a new era of rice genomics aimed at bridging the knowledge gap between genotype and phenotype in rice. These technologies have also led to pyramid breeding through genomics-assisted selection, which will be useful in breeding elite varieties suitable for sustainable agriculture. Here, we review the recent advances in rice genomics and discuss the future of this line of research.

摘要

水稻是作物基因组学研究的模式系统。早期的水稻基因组学研究主要集中在分析全基因组遗传变异,以进一步了解水稻基因在农艺性状中的功能,并为水稻研究生成数据和资源。高通量 DNA 测序技术的出现和高质量参考基因组序列的完成,使得基于测序的基因分型和全基因组关联研究(GWAS)得以发展,这极大地推动了水稻遗传学研究。这导致了一个旨在弥合水稻基因型和表型之间知识差距的新的水稻基因组学时代的出现。这些技术还通过基因组辅助选择导致了金字塔式的育种,这将有助于培育适合可持续农业的优良品种。在这里,我们回顾了水稻基因组学的最新进展,并讨论了这一研究领域的未来。

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