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高渗盐水溶液可降低内毒素血症大鼠的炎症反应。

Hypertonic saline solution reduces the inflammatory response in endotoxemic rats.

机构信息

Faculdade de Medicina da Universidade de São Paulo, Emergency Medicine Division, São Paulo/SP, Brazil.

出版信息

Clinics (Sao Paulo). 2012 Dec;67(12):1463-8. doi: 10.6061/clinics/2012(12)18.

DOI:10.6061/clinics/2012(12)18
PMID:23295602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3521811/
Abstract

OBJECTIVE

Volume replacement in septic patients improves hemodynamic stability. This effect can reduce the inflammatory response. The objective of this study was to evaluate the effect of 7.5% hypertonic saline solution versus 0.9% normal saline solution for volume replacement during an inflammatory response in endotoxemic rats.

METHODS

We measured cytokines (serum and gut), nitrite, and lipid peroxidation (TBARS) as indicators of oxidative stress in the gut. Rats were divided into four groups: control group (C) that did not receive lipopolysaccharide; lipopolysaccharide injection without treatment (LPS); lipopolysaccharide injection with saline treatment (LPS +S); and lipopolysaccharide injection with hypertonic saline treatment (LPS +H). Serum and intestine were collected. Measurements were taken at 1.5, 8, and 24 h after lipopolysaccharide administration.

RESULTS

Of the four groups, the LPS +H group had the highest survival rate. Hypertonic saline solution treatment led to lower levels of IL-6, IL-10, nitric oxide, and thiobarbituric acid reactive substances compared to 0.9% normal saline. In addition, hypertonic saline treatment resulted in a lower mortality compared to 0.9% normal saline treatment in endotoxemic rats. Volume replacement reduced levels of inflammatory mediators in the plasma and gut.

CONCLUSION

Hypertonic saline treatment reduced mortality and lowered levels of inflammatory mediators in endotoxemic rats. Hypertonic saline also has the advantage of requiring less volume replacement.

摘要

目的

脓毒症患者的容量复苏可改善血流动力学稳定性，从而减轻炎症反应。本研究旨在评估在肠源性内毒素血症大鼠模型中，高渗盐水（7.5%）与生理盐水（0.9%）用于容量复苏时对炎症反应的影响。

方法

通过检测血清和肠道细胞因子（白细胞介素-6 和白细胞介素-10）、硝酸盐（作为氧化应激的指标）和脂质过氧化（丙二醛），评估氧化应激情况。大鼠随机分为 4 组：未接受脂多糖（C 组）；注射脂多糖但未治疗（LPS 组）；注射脂多糖并给予生理盐水治疗（LPS+S 组）；注射脂多糖并给予高渗盐水治疗（LPS+H 组）。于脂多糖给药后 1.5、8 和 24 h 时收集血清和肠道标本。

结果

与 LPS+S 组相比，LPS+H 组大鼠的存活率最高。与 LPS+S 组相比，LPS+H 组大鼠的白细胞介素-6、白细胞介素-10、一氧化氮和丙二醛水平均较低。此外，与 LPS+S 组相比，LPS+H 组大鼠的死亡率较低。容量复苏降低了血浆和肠道中炎症介质的水平。

结论

高渗盐水治疗可降低肠源性内毒素血症大鼠的死亡率，降低炎症介质水平，且所需的容量复苏更少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/d950dd4ae191/cln-67-12-1463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/ba84e017eea2/cln-67-12-1463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/e18783d58800/cln-67-12-1463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/b0ae7e25b768/cln-67-12-1463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/d950dd4ae191/cln-67-12-1463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/ba84e017eea2/cln-67-12-1463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/e18783d58800/cln-67-12-1463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/b0ae7e25b768/cln-67-12-1463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c6e/3521811/d950dd4ae191/cln-67-12-1463-g005.jpg

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