Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Age Ageing. 2013 Mar;42(2):191-6. doi: 10.1093/ageing/afs185. Epub 2013 Jan 7.
to evaluate the relationship between neurocognitive speed (NCS) and frailty; to consider how this relationship is affected by how frailty is operationalised.
secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort.
of 388 participants who underwent a comprehensive intake assessment followed by an annual follow-up for at least 3 years, data on all measures were available on 164 people.
NCS was defined as a combined score of <18 on the pattern comparison test (<11 is abnormal) and letter comparison test (<7 is abnormal). Frailty was defined from a modified Phenotype model, the Edmonton Frailty Scales (EFS) and a frailty index (FI); the latter two were adapted here to exclude cognitive measures.
in multivariate logistic (NCS as < or ≥18) and linear regression (NCS as continuous variable), only the FI (OR = 0.87) was significant (P < 0.05). When all frailty measures were included in the multivariate analysis only, FI (OR = 0.88) was significant (P < 0.05). Mini-mental Status Examination remained significantly related to NCS throughout all analysis.
NCS slows with increasing frailty as shown with the FI.
评估神经认知速度（NCS）与虚弱之间的关系；考虑如何根据虚弱的操作方式来影响这种关系。
牛津记忆与衰老项目（OPTIMA）基线队列的二次分析，这是一个纵向观察队列。
在接受全面的摄入评估后，有 388 名参与者进行了每年至少 3 年的随访，其中 164 人的所有指标数据都可用。
NCS 的定义为模式比较测试（<11 异常）和字母比较测试（<7 异常）的综合评分<18。虚弱是根据改良表型模型、埃德蒙顿虚弱量表（EFS）和虚弱指数（FI）定义的；后两者在这里被改编以排除认知测量。
在多变量逻辑（NCS 为<或≥18）和线性回归（NCS 为连续变量）中，只有 FI（OR=0.87）有意义（P<0.05）。当所有的虚弱指标都只包含在多变量分析中时，FI（OR=0.88）才有意义（P<0.05）。简易精神状态检查（Mini-mental Status Examination）在所有分析中仍与 NCS 显著相关。
FI 显示，随着虚弱程度的增加，NCS 会减慢。
