神经认知速度与虚弱的关系评估。

An assessment of neurocognitive speed in relation to frailty.

机构信息

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

出版信息

Age Ageing. 2013 Mar;42(2):191-6. doi: 10.1093/ageing/afs185. Epub 2013 Jan 7.

DOI:10.1093/ageing/afs185

PMID:23296141

Abstract

OBJECTIVES

to evaluate the relationship between neurocognitive speed (NCS) and frailty; to consider how this relationship is affected by how frailty is operationalised.

DESIGN

secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort.

SUBJECTS

of 388 participants who underwent a comprehensive intake assessment followed by an annual follow-up for at least 3 years, data on all measures were available on 164 people.

MEASUREMENTS

NCS was defined as a combined score of <18 on the pattern comparison test (<11 is abnormal) and letter comparison test (<7 is abnormal). Frailty was defined from a modified Phenotype model, the Edmonton Frailty Scales (EFS) and a frailty index (FI); the latter two were adapted here to exclude cognitive measures.

RESULTS

in multivariate logistic (NCS as < or ≥18) and linear regression (NCS as continuous variable), only the FI (OR = 0.87) was significant (P < 0.05). When all frailty measures were included in the multivariate analysis only, FI (OR = 0.88) was significant (P < 0.05). Mini-mental Status Examination remained significantly related to NCS throughout all analysis.

CONCLUSION

NCS slows with increasing frailty as shown with the FI.

摘要

目的

评估神经认知速度（NCS）与虚弱之间的关系；考虑如何根据虚弱的操作方式来影响这种关系。

设计

牛津记忆与衰老项目（OPTIMA）基线队列的二次分析，这是一个纵向观察队列。

受试者

在接受全面的摄入评估后，有 388 名参与者进行了每年至少 3 年的随访，其中 164 人的所有指标数据都可用。

测量

NCS 的定义为模式比较测试（<11 异常）和字母比较测试（<7 异常）的综合评分<18。虚弱是根据改良表型模型、埃德蒙顿虚弱量表（EFS）和虚弱指数（FI）定义的；后两者在这里被改编以排除认知测量。

结果

在多变量逻辑（NCS 为<或≥18）和线性回归（NCS 为连续变量）中，只有 FI（OR=0.87）有意义（P<0.05）。当所有的虚弱指标都只包含在多变量分析中时，FI（OR=0.88）才有意义（P<0.05）。简易精神状态检查（Mini-mental Status Examination）在所有分析中仍与 NCS 显著相关。