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2012 年的骨关节炎:OA 表型和治疗方法的平行演变。

Osteoarthritis in 2012: Parallel evolution of OA phenotypes and therapies.

机构信息

Division of Musculoskeletal Disease, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds LS7 4SA, UK.

出版信息

Nat Rev Rheumatol. 2013 Feb;9(2):68-70. doi: 10.1038/nrrheum.2012.225. Epub 2013 Jan 8.

DOI:10.1038/nrrheum.2012.225
PMID:23296390
Abstract

2012 has witnessed new developments in targeted therapies for osteoarthritis, and in ways to identify those patients who might benefit most from their application. Together, these advances could go some way to addressing the urgent need for disease-modifying treatments for this common disease.

摘要

2012 年见证了针对骨关节炎的靶向治疗的新进展,以及识别那些可能最受益于其应用的患者的方法。这些进展共同为满足这种常见疾病对疾病修正治疗的迫切需求提供了一些可能的途径。

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本文引用的文献

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Targeting tumour necrosis factor alleviates signs and symptoms of inflammatory osteoarthritis of the knee.靶向肿瘤坏死因子可缓解膝部炎性骨关节炎的体征和症状。
Arthritis Res Ther. 2012 Oct 4;14(5):R206. doi: 10.1186/ar4044.
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Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study).在没有膝骨关节炎的成年人中,通过 MRI 检测到的膝关节异常的流行率:基于人群的观察性研究(弗雷明汉骨关节炎研究)。
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Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells.
康复在原发性膝关节骨关节炎中的重要性。
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Current concepts in joint pain in knee osteoarthritis.膝关节骨关节炎关节疼痛的当前概念
Schmerz. 2019 Feb;33(1):22-29. doi: 10.1007/s00482-018-0275-9.
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Injectable nanohydroxyapatite-chitosan-gelatin micro-scaffolds induce regeneration of knee subchondral bone lesions.可注射纳米羟磷灰石-壳聚糖-明胶微支架诱导膝关节软骨下骨病变再生。
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Sanguinarine protects against osteoarthritis by suppressing the expression of catabolic proteases.血根碱通过抑制分解代谢蛋白酶的表达来预防骨关节炎。
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Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage.骨关节炎软骨中细胞因子、基质金属蛋白酶和纤连蛋白片段的数学建模
J Math Biol. 2017 Oct;75(4):985-1024. doi: 10.1007/s00285-017-1104-y. Epub 2017 Feb 17.
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Proliferative injection therapy for osteoarthritis: a systematic review.骨关节炎的增殖性注射疗法:一项系统评价
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