妊娠合并贫血：评估在疟疾流行地区常规预防措施的效果。
Maternal anemia in pregnancy: assessing the effect of routine preventive measures in a malaria-endemic area.
机构信息
Unité Mixte de Recherche 216, Mère et Enfant Face aux Infections Tropicales, Paris, France.
出版信息
Am J Trop Med Hyg. 2013 Feb;88(2):292-300. doi: 10.4269/ajtmh.12-0195. Epub 2013 Jan 7.
Abstract
We investigated the effectiveness of routine preventive measures for anemia in Beninese pregnant women during pregnancy. Anemia (hemoglobin < 110 g/L) was common: 68.3% at first antenatal visit (ANV1), 64.7% at second antenatal visit (ANV2), and 40.6% at delivery. Parasitic infections and nutritional deficiencies were the most preventable causes. After intermittent preventive treatment (IPTp) and antihelminthic treatments, malaria prevalence decreased from 15.1% (ANV1) to 4.0% (ANV2) and increased again to 9.6% at delivery. Helminth infections dropped from 11.1% (ANV1) to 7.2% (ANV2) and 2.4% at delivery. Malaria was associated with lower mean hemoglobin on ANV1 and delivery, and iron deficiency was associated with lower mean hemoglobin on ANV1 and ANV2. IPTp and antihelminthic treatments were efficacious to clear parasitic infections and improve hematologic status, whereas the effectiveness of daily iron and folic acid supplements to correct iron and folate deficiencies and decrease anemia was less marked, possibly because of lack of compliance.
摘要
我们研究了贝宁孕妇在怀孕期间常规预防贫血的措施的有效性。贫血（血红蛋白<110g/L）很常见：第一次产前检查（ANV1）时为 68.3%，第二次产前检查（ANV2）时为 64.7%，分娩时为 40.6%。寄生虫感染和营养缺乏是最可预防的原因。间歇性预防治疗（IPTp）和驱虫治疗后，疟疾的患病率从 15.1%（ANV1）下降到 4.0%（ANV2），分娩时又上升到 9.6%。寄生虫感染从 11.1%（ANV1）下降到 7.2%（ANV2）和分娩时的 2.4%。疟疾与 ANV1 和分娩时的平均血红蛋白水平较低有关，而缺铁与 ANV1 和 ANV2 时的平均血红蛋白水平较低有关。IPTp 和驱虫治疗对清除寄生虫感染和改善血液状况有效，而每日铁和叶酸补充剂纠正铁和叶酸缺乏症和减少贫血的效果不那么显著，可能是因为缺乏依从性。
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