Federal University of Paraná, Curitiba, Paraná, Brazil.
Rheumatol Int. 2013 Jul;33(7):1779-83. doi: 10.1007/s00296-012-2631-x. Epub 2013 Jan 8.
The objective of the study was to investigate the association between IL-8 and other biomarkers of endothelial dysfunction (MCP-1, V-CAM, I-CAM) and the disease activity scores in a sample of 54 patients with ankylosing spondylitis (AS) without use of biological agents. Fifty-four AS patients without treatment with anti-TNFs agents between 18 and 80 years old, who met modified New York criteria and at the same time the axial ASAS criteria, were evaluated using an epidemiological questionnaire that included among others clinical data, BASDAI, BASFI, ASQoL, ASDAS and plasma levels of CRP, ESR, MCP-1, IL-8, ICAM-1 and VCAM-1. IL-8 varied in proportion to disease activity rates (BASDAI and ASDAS) p < 0.05, being strongly correlated with the disease activity. The levels of adhesion molecules I-CAM and VCAM, as described in other studies, were positively correlated with predisposing factors for cardiovascular disease. IL-8 has shown to be strongly correlated with clinical markers of disease activity and inflammatory activity and may be an additional variable to the overall assessment of the activity of the AS.
本研究旨在调查白细胞介素 8（IL-8）与其他血管内皮功能障碍生物标志物（MCP-1、V-CAM、I-CAM）以及 54 例未使用生物制剂的强直性脊柱炎（AS）患者疾病活动评分之间的相关性。54 例年龄在 18 至 80 岁之间的未接受抗 TNF 治疗的 AS 患者，符合改良纽约标准和同时满足轴性 ASAS 标准，通过包括临床数据、BASDAI、BASFI、ASQoL、ASDAS 和 CRP、ESR、MCP-1、IL-8、ICAM-1 和 VCAM-1 等指标的流行病学问卷进行评估。IL-8 与疾病活动率（BASDAI 和 ASDAS）呈比例变化，p<0.05，与疾病活动呈强相关性。与其他研究中描述的黏附分子 I-CAM 和 VCAM 一样，这些黏附分子的水平与心血管疾病的易患因素呈正相关。IL-8 与疾病活动和炎症活动的临床标志物呈强相关性，可能是 AS 活动总体评估的一个附加变量。
