Zhang Yang, Wei Qiangman, Chen Qianzhi
Exercise Biological Research Center, China Institute of Sport Science, Beijing, 100061, China.
Poatal Savings Bank of China Co, Ltd., Beijing, 100808, China.
Sci Rep. 2024 Dec 16;14(1):30467. doi: 10.1038/s41598-024-82732-w.
Although atopic dermatitis (AD) and type 2 diabetes mellitus (T2DM) may appear clinically and pathophysiologically unrelated, AD is a common skin disease characterized by chronic inflammation and skin barrier dysfunction, whereas T2DM is a metabolic disorder marked by hyperglycemia and chronic inflammation, which further exacerbates insulin resistance (IR) through the release of systemic inflammatory factors. Despite their apparent differences, the molecular mechanisms shared between AD and T2DM remain relatively unexplored. In this study, we integrated transcriptomic data from both AD and T2DM using differential gene expression analyses (DEGs), gene set variation analysis (GSVA), and machine learning algorithms to uncover common features of these diseases. We identified several characteristic genes, including LTF, LTB4R, and CCR1, which are significantly upregulated in both conditions and may serve as potential biomarkers. Furthermore, virtual screening revealed that Dioscin, Camptothecin, and Albamycin exhibit strong affinity for the CCR1 binding site, indicating their potential as therapeutic candidates. In summary, this study elucidates the shared molecular mechanisms of AD and T2DM and introduces new potential targets and drugs for the diagnosis and treatment of these diseases.
虽然特应性皮炎（AD）和2型糖尿病（T2DM）在临床和病理生理上可能看似无关，但AD是一种以慢性炎症和皮肤屏障功能障碍为特征的常见皮肤病，而T2DM是一种以高血糖和慢性炎症为特征的代谢紊乱疾病，其通过全身性炎症因子的释放进一步加剧胰岛素抵抗（IR）。尽管它们存在明显差异，但AD和T2DM之间共有的分子机制仍相对未被探索。在本研究中，我们使用差异基因表达分析（DEG）、基因集变异分析（GSVA）和机器学习算法整合了来自AD和T2DM的转录组数据，以揭示这些疾病的共同特征。我们鉴定出了几个特征基因，包括LTF、LTB4R和CCR1，它们在这两种疾病中均显著上调，可能作为潜在的生物标志物。此外，虚拟筛选显示薯蓣皂苷、喜树碱和阿巴霉素对CCR1结合位点具有很强的亲和力，表明它们作为治疗候选药物的潜力。总之，本研究阐明了AD和T2DM共有的分子机制，并为这些疾病的诊断和治疗引入了新的潜在靶点和药物。
