Sakina M R, Dandiya P C, Hamdard M E, Hameed A
Institute of History of Medicine and Medical Research, Hamdard Nagar, New Delhi, India.
J Ethnopharmacol. 1990 Feb;28(2):143-50. doi: 10.1016/0378-8741(90)90023-m.
An ethanol extract of the leaves of Ocimum sanctum was screened for its effects on the central nervous system. It prolonged the time of lost reflex in mice due to pentobarbital, decreased the recovery time and severity of electroshock- and pentylenetetrazole-induced convulsions, and decreased apomorphine-induced fighting time and ambulation in "open field" studies. Using a behavioural despair model involving forced swimming in rats and mice, the extract lowered immobility in a manner comparable to imipramine. This action was blocked by haloperidol and sulpiride, indicating a possible action involving dopaminergic neurones. In similar studies, there was a synergistic action when the extract was combined with bromocriptine, a potent D2-receptor agonist.
对神圣罗勒叶的乙醇提取物进行了中枢神经系统作用筛选。它延长了小鼠因戊巴比妥导致的反射消失时间，缩短了电休克和戊四氮诱导惊厥的恢复时间及严重程度，在“旷场”实验中减少了阿扑吗啡诱导的打斗时间和活动。在涉及大鼠和小鼠强迫游泳的行为绝望模型中，该提取物以与丙咪嗪相当的方式降低了不动时间。这种作用被氟哌啶醇和舒必利阻断，表明可能涉及多巴胺能神经元的作用。在类似研究中，当提取物与强效D2受体激动剂溴隐亭合用时存在协同作用。
