Kasture V S, Chopde C T, Deshmukh V K
N.D.M.V.P. Samaj's College of Pharmacy, 422002, Nasik, India.
J Ethnopharmacol. 2000 Jul;71(1-2):65-75. doi: 10.1016/s0378-8741(99)00192-0.
The ethanolic extracts of leaves of Albizzia lebbeck and flowers of Hibiscus rosa sinesis and the petroleum ether extract of flowers of Butea monosperma exhibited anticonvulsant activity. The bioassay guided fractionation indicated that the anticonvulsant activity lies in the methanolic fraction of chloroform soluble part of ethanolic extract of the leaves of A. lebbeck, acetone soluble part of ethanolic extract of H. rosa sinesis flowers and acetone soluble part of petroleum ether extract of B. monosperma flowers. The fractions protected animals from maximum electro shock, electrical kindling and pentylenetetrazole-induced convulsions in mice. The fractions also inhibited convulsions induced by lithium-pilocarpine and electrical kindling. However, they failed to protect animals from strychnine-induced convulsions. The fractions antagonised the behavioral effects of D-amphetamine and potentiated the pentobarbitone-induced sleep. The fractions raised brain contents of gamma-aminobutyric acid (GABA) and serotonin. These fractions were found to be anxiogenic and general depressant of central nervous system.
无忧树叶片的乙醇提取物、朱槿花的乙醇提取物以及紫铆花的石油醚提取物均表现出抗惊厥活性。生物测定导向的分级分离表明，抗惊厥活性存在于无忧树叶片乙醇提取物氯仿可溶部分的甲醇级分、朱槿花乙醇提取物丙酮可溶部分以及紫铆花石油醚提取物丙酮可溶部分中。这些级分可保护小鼠免受最大电休克、电点燃和戊四氮诱导的惊厥。这些级分还可抑制锂 - 匹罗卡品和电点燃诱导的惊厥。然而，它们未能保护动物免受士的宁诱导的惊厥。这些级分拮抗了D - 苯丙胺的行为效应并增强了戊巴比妥诱导的睡眠。这些级分提高了γ - 氨基丁酸（GABA）和血清素的脑含量。发现这些级分具有致焦虑作用且是中枢神经系统的一般抑制剂。
