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尼日利亚东南部纽伊新诊断高血压患者的血脂谱

Serum lipid profile of newly diagnosed hypertensive patients in nnewi, South-East Nigeria.

作者信息

Osuji Charles U, Omejua Emeka G, Onwubuya Emmanuel I, Ahaneku Gladys I

机构信息

Department of Medicine, Nnamdi Azikiwe University Teaching Hospital, PMB 5025, Nnewi 435101, Anambra State, Nigeria.

出版信息

Int J Hypertens. 2012;2012:710486. doi: 10.1155/2012/710486. Epub 2012 Dec 4.

Abstract

Abnormalities in serum lipid and lipoprotein levels are recognized major modifiable cardiovascular disease and essential hypertension risk factors. The objective of this study was to examine the serum lipid patterns of newly diagnosed hypertensive patients attending a tertiary healthcare centre in South East Nigeria. Methods. Two hundred and fifty newly diagnosed adult hypertensive patients and an equal number of age- and sex-matched controls without hypertension were consecutively recruited from the Medical and General Outpatient Clinics of Nnamdi Azikiwe University Teaching Hospital, Nnewi. Result. 126 males and 124 females were in each of the two groups. Mean age was comparable in both groups. Hypertensives had significantly higher mean systolic blood pressure, diastolic blood pressure, body mass index, waist circumference, waist-hip ratio, and fasting blood sugar than the controls. The mean TC, TG, and LDL-C were significantly higher among the hypertensives. The mean HDL-C was comparable; P = 0.8. Among the hypertensive subjects, there was statistically significant positive correlation between BMI and TC; LDL-C and TG; WC and TG; FBS and TC; LDL-C and TG. HDL-C showed a statistically significant inverse correlation with WHR in hypertensives. Conclusion. This study showed that lipid abnormalities are highly prevalent among newly diagnosed hypertensives in South-East Nigeria.

摘要

血清脂质和脂蛋白水平异常是公认的主要可改变的心血管疾病和原发性高血压风险因素。本研究的目的是调查在尼日利亚东南部一家三级医疗中心就诊的新诊断高血压患者的血清脂质模式。方法。从Nnewi的Nnamdi Azikiwe大学教学医院的内科和普通门诊连续招募了250名新诊断的成年高血压患者以及同等数量的年龄和性别匹配的无高血压对照者。结果。两组各有126名男性和124名女性。两组的平均年龄相当。高血压患者的平均收缩压、舒张压、体重指数、腰围、腰臀比和空腹血糖均显著高于对照组。高血压患者的平均总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)显著更高。平均高密度脂蛋白胆固醇(HDL-C)相当;P = 0.8。在高血压受试者中,体重指数与总胆固醇、低密度脂蛋白胆固醇与甘油三酯、腰围与甘油三酯、空腹血糖与总胆固醇、低密度脂蛋白胆固醇与甘油三酯之间存在统计学上显著的正相关。高血压患者中,高密度脂蛋白胆固醇与腰臀比呈统计学上显著的负相关。结论。本研究表明,在尼日利亚东南部新诊断的高血压患者中,脂质异常非常普遍。

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