Maternity Research Center, Department of Gynecology and Obstetrics, Kermanshah University of Medical Sciences.
Phytother Res. 2013 Nov;27(11):1708-13. doi: 10.1002/ptr.4921. Epub 2013 Jan 11.
Pharmacological treatments of polycystic ovary syndrome (PCOS) have side effects. We compared the efficacy and safety of the aerial parts of wood botany (AWB) with those of Medroxyprogesterone acetate (MPA) in the management of abnormal uterine bleeding (AUB) due to PCOS. We conducted a randomized clinical trial of 66 women aged 15-45 years, with AUB. Participants were randomly assigned to either cyclical 10-mg BD MPA for three cycles or 5 g ABW TDS for three months. Clinical symptoms and paraclinical parameters were recorded before and 3 months after initiation of the treatment. Comparisons were made using generalized linear models. Age-adjusted prevalence rate of different patterns of AUB, decreased from 2.7 (95%CIs: 0.6-48.0) to 1.1 (95%CIs: 0.1-18.3) for patients taking MPA, and from 2.5 (95% CIs: 0.2-40.2) to 0.7 (95%CIs: 0.0-12.1). Decrease in prevalence rate was similar across two arms of the study (P value = 0.248). Adverse effects were observed less frequently (24.2%) among participants on MPA than among those on AWB (45.5%). The multivariate-adjusted odds for developing adverse reaction of MPA was 0.40 (95%CIs: 0.14-1.19, P value = 0.099) time odds of AWB. In conclusion, AWB may be used as an alternative for MPA in the treatment of AUB caused by PCOS.
多囊卵巢综合征 (PCOS) 的药物治疗有副作用。我们比较了木本草（AWB）与醋酸甲羟孕酮（MPA）在治疗 PCOS 引起的异常子宫出血（AUB）方面的疗效和安全性。我们进行了一项随机临床试验，纳入了 66 名年龄在 15-45 岁之间、有 AUB 症状的女性。参与者被随机分为三组，分别接受周期性 10mg BD MPA 治疗三个周期、周期性 5g ABW TDS 治疗三个疗程或安慰剂治疗。在治疗前和治疗 3 个月后记录临床症状和实验室参数。使用广义线性模型进行比较。年龄调整后的不同 AUB 模式的患病率从 MPA 组的 2.7（95%CI：0.6-48.0）下降到 1.1（95%CI：0.1-18.3），从 AWB 组的 2.5（95%CI：0.2-40.2）下降到 0.7（95%CI：0.0-12.1）。两种治疗方法的患病率下降情况相似（P 值=0.248）。MPA 组的不良反应发生率（24.2%）低于 AWB 组（45.5%）。多变量调整后的 MPA 发生不良反应的比值比为 0.40（95%CI：0.14-1.19，P 值=0.099），即 AWB 的时间比值比。综上所述，AWB 可作为治疗 PCOS 引起的 AUB 的 MPA 替代药物。
