Kwon Ho Jang, Jin Han Jun, Lim Myung Ho
1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea .
Genet Test Mol Biomarkers. 2014 Jul;18(7):505-9. doi: 10.1089/gtmb.2014.0066. Epub 2014 Jun 30.
Attention deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is familial and genetic studies estimate heritability at 80-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the monoamine oxidase (MAO) gene in Korean children with ADHD. The sample consisted of 180 ADHD children and 159 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 339 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for MAO polymorphism. Allele and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of MAO gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of the rs5906883 (odds ratio [OR]=1.47, 95% confidence interval [CI]=1.08-2.00, p=0.014) and the rs3027407 (OR=1.41, 95% CI=1.03-1.91, p=0.029) alleles of MAO, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that MAO might be related to ADHD symptoms.
注意缺陷多动障碍（ADHD）是学龄儿童中的一种常见疾病。ADHD具有家族性，遗传研究估计其遗传度为80%-90%。本研究的目的是调查韩国ADHD儿童单胺氧化酶（MAO）基因的基因类型和等位基因之间的关联。样本包括180名ADHD儿童和159名对照儿童。我们根据《精神疾病诊断与统计手册》第四版（DSM-IV）诊断ADHD。使用康纳斯父母评定量表和杜保罗父母ADHD评定量表评估ADHD症状。从339名受试者采集血样，从血淋巴细胞中提取DNA，并对MAO多态性进行聚合酶链反应。使用卡方检验比较等位基因和基因型频率。我们比较了ADHD组和对照组中MAO基因多态性的等位基因和基因型频率。本研究表明，MAO的rs5906883（优势比[OR]=1.47，95%置信区间[CI]=1.08-2.00，p=0.014）和rs3027407（OR=1.41，95%CI=1.03-1.91，p=0.029）等位基因频率之间存在显著相关性，但最终结论并不确定。预计将对更大的患者群体或纯亚组进行后续研究。这些结果表明MAO可能与ADHD症状有关。
