Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alzheimers Dement. 2018 Nov;14(11):1406-1415. doi: 10.1016/j.jalz.2018.03.011. Epub 2018 May 12.
The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.
In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.
In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.
Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.
中年时期血管危险因素与认知功能相互作用，与晚年轻度认知障碍（MCI）和痴呆（DEM）的关系尚不清楚。
在动脉粥样硬化风险社区研究中，评估了中年时期（45-64 岁）的心血管危险因素和认知功能。2011-2013 年，20-25 年后，所有同意参与动脉粥样硬化风险社区研究的参与者都接受了认知和神经学评估，并被给予认知正常、MCI 或 DEM 的明确诊断。
在 5995 名具有完整协变量数据的参与者中，中年时期的糖尿病、高血压、肥胖和高胆固醇血症与晚年的 MCI 和 DEM 相关。中年时期认知功能较低也与晚年 MCI 或 DEM 的可能性更大相关。当两者都在模型中时，中年时期的血管危险因素和认知功能都与晚年的 MCI 或 DEM 相关。
晚年 MCI 和 DEM 与中年时期的血管危险因素和认知功能独立相关。
