Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
FEBS Lett. 2013 Feb 14;587(4):358-63. doi: 10.1016/j.febslet.2012.12.017. Epub 2013 Jan 8.
Sox11 and Sox4 play critical roles in retinal development, during which they display specific and unique expression patterns. The expression of Sox11 and Sox4 is temporally sequential, albeit spatially overlapping in some retinal subtypes. Gain-of-function and loss-of-function analyses suggested that Notch signaling suppresses Sox4 expression in the early developing retina but not during the later period of development. The levels of histone H3-acetylation and H3-lysine 4 tri-methylation at the Sox11 locus declined during development, as did the levels of Sox11. A similar but less marked change was seen for Sox4. For both genes, histone H3-lysine 27 methylation was low during development and increased markedly in the adult.
Sox11 和 Sox4 在视网膜发育过程中发挥着关键作用，在此期间，它们表现出特定且独特的表达模式。Sox11 和 Sox4 的表达具有时间顺序性，尽管在某些视网膜亚型中存在空间重叠。功能获得和功能丧失分析表明，Notch 信号在早期发育的视网膜中抑制 Sox4 的表达，但不在后期发育中抑制。Sox11 基因座处组蛋白 H3-乙酰化和 H3-赖氨酸 4 三甲基化的水平在发育过程中下降，Sox11 的水平也随之下降。Sox4 的情况类似但不那么明显。对于这两个基因，组蛋白 H3-赖氨酸 27 甲基化在发育过程中较低，在成年期显著增加。
