Rahman Adeeb H, Aloman Costica
Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA.
Biochim Biophys Acta. 2013 Jul;1832(7):998-1004. doi: 10.1016/j.bbadis.2013.01.005. Epub 2013 Jan 9.
Dendritic cells are a relative rare population of specialized antigen presenting cells that are distributed through most lymphoid and non-lymphoid tissues and play a critical role in linking the innate and adaptive arms of the immune system. The liver contains a heterogeneous population of dendritic cells that may contribute to liver inflammation and fibrosis through a number of mechanisms. This review summarizes current knowledge on the development and characterization of liver dendritic cells and their potential impact on liver fibrosis. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
树突状细胞是一类相对罕见的特殊抗原呈递细胞，分布于大多数淋巴组织和非淋巴组织中，在连接免疫系统的固有免疫和适应性免疫分支方面发挥着关键作用。肝脏中含有异质性的树突状细胞群体，它们可能通过多种机制导致肝脏炎症和纤维化。本综述总结了目前关于肝脏树突状细胞的发育、特征及其对肝纤维化潜在影响的知识。本文是名为《纤维化：基础研究向人类疾病的转化》特刊的一部分。
