Department of General Pathology, Second University of Naples, Vico L. de Crecchio 7, 80138 Napoli, Italy.
Food Chem Toxicol. 2013 May;55:304-12. doi: 10.1016/j.fct.2012.12.048. Epub 2013 Jan 11.
Solanum tuberosum L. var. Vitelotte is a potato variety widely used for human consumption. The pigments responsible for its attractive color belong to the class of anthocyanins. The objectives of this study were to characterize and measure the concentration of anthocyanins in pigmented potatoes and to evaluate their antioxidant and antimicrobial activities and their anti-proliferative effects in solid and hematological cancer cell lines. Anthocyanins exert anti-bacterial activity against different bacterial strains and a slight activity against three fungal strains. The Gram-positive bacterium Staphylococcus aureus and the fungus Rhyzoctonia solani were the most affected microorganisms. Antioxidant activities were evaluated by DPPH and FRAP methods; the extract showed a higher reducing capability than anti-radical activity. Moreover, we found that in different cancer cell models the anthocyanins cause inhibition of proliferation and apoptosis in a dose dependent manner. These biological activities are likely due to the high content of malvidin 3-O-p-coumaroyl-rutinoside-5-O-glucoside and petunidin 3-O-p-coumaroyl-rutinoside-5-O-glucoside.
马铃薯品种维特罗勒（Solanum tuberosum L. var. Vitelotte）广泛用于人类食用。赋予其诱人色泽的色素属于花色苷类。本研究的目的是对有色马铃薯中的花色苷进行特征描述和浓度测定，并评估其在固体和血液癌细胞系中的抗氧化和抗菌活性以及抗增殖作用。花色苷对不同的细菌菌株具有抗细菌活性，对三种真菌菌株具有轻微的活性。革兰氏阳性菌金黄色葡萄球菌和真菌立枯丝核菌是受影响最大的微生物。抗氧化活性通过 DPPH 和 FRAP 方法进行评估；提取物表现出比抗自由基活性更高的还原能力。此外，我们发现，在不同的癌症细胞模型中，花色苷以剂量依赖的方式引起增殖抑制和细胞凋亡。这些生物活性可能归因于大量的矢车菊素 3-O-对香豆酰基-芦丁糖苷-5-O-葡萄糖苷和飞燕草素 3-O-对香豆酰基-芦丁糖苷-5-O-葡萄糖苷。
