基于萨宾株的含佐剂灭活脊髓灰质炎疫苗的抗原节约。
Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.
机构信息
Institute for Translational Vaccinology, Antonie van Leeuwenhoeklaan 9, 3720 AL Bilthoven, The Netherlands.
出版信息
Vaccine. 2013 Feb 18;31(9):1298-304. doi: 10.1016/j.vaccine.2012.12.076. Epub 2013 Jan 9.
Abstract
Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants.
摘要
六种不同的佐剂，每种均与减毒的 Sabin 株（sIPV）制成的灭活脊髓灰质炎疫苗（IPV）联合使用，在大鼠效力模型中评估其增强病毒中和抗体滴度（VNTs）的能力。佐剂分别使 1、2 和 3 型血清型的 VNTs 在一次免疫后平均增加 3 倍、15 倍和 24 倍。在加强免疫后，与无佐剂的 sIPV 两次接种相比，佐剂增强的 sIPV 的 VNTs 平均又提高了 7-20-27 倍。结果表明，使用佐剂来提高灭活脊髓灰质炎疫苗的效力是可行的。
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