Wound Healing Research Unit, Department of Dermatology, University of Pisa, Pisa, Italy.
Curr Opin Support Palliat Care. 2013 Mar;7(1):106-10. doi: 10.1097/SPC.0b013e32835dc0fc.
Wound healing research has progressed impressively over the past years. New insights into the pathogenesis of different chronic wounds and the study of novel treatment have made wound healing a model disorder and have revealed basic cellular and molecular mechanisms underlying chronic wounds. Although the observation is so obvious and simple, the interpretations by different observers can be quite variable. The interpretations of severity and change in severity by treatment may differ considerably between patient and practitioners.
In this review we provide comprehensive view on different aspects of wound diagnostic, including clinical measurement, new biomarkers in wound pathology, proteases evaluation, and future noninvasive sensor-based devices.
Wound caregivers are in the unique position of being able to observe the wound changes and describe these with knowledge and strict methodology, but also with the wide range of available wound diagnostic devices. The complexity of severity assessment in wound healing is reflected by the multiple clinical scores available. The best objective methods used to evaluate cutaneous tissue repair should have a high specificity and sensitivity and a low inter and intraobserver variation.
在过去的几年中，伤口愈合研究取得了令人瞩目的进展。对不同慢性伤口发病机制的新认识和新治疗方法的研究使伤口愈合成为一种典型的疾病模型，并揭示了慢性伤口的基本细胞和分子机制。尽管观察结果如此明显和简单，但不同观察者的解释可能存在很大差异。治疗对严重程度和严重程度变化的解释在患者和从业者之间可能有很大差异。
在这篇综述中，我们提供了伤口诊断的不同方面的全面观点，包括临床测量、伤口病理学中的新型生物标志物、蛋白酶评估以及未来的非侵入性基于传感器的设备。
伤口护理人员具有独特的优势，能够观察伤口的变化，并凭借专业知识和严格的方法进行描述，但也需要广泛的伤口诊断设备。伤口愈合严重程度评估的复杂性反映在多种临床评分的应用上。用于评估皮肤组织修复的最佳客观方法应具有高特异性和敏感性以及低的观察者内和观察者间变异性。
