大环内酯类药物治疗慢性鼻-鼻窦炎：荟萃分析。
Macrolide therapy for chronic rhinosinusitis: a meta-analysis.
机构信息
Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA.
出版信息
Otolaryngol Head Neck Surg. 2013 Mar;148(3):366-73. doi: 10.1177/0194599812470427. Epub 2013 Jan 11.
Abstract
OBJECTIVE
The objective of this study was to systematically review patient-reported outcomes of long-term macrolide therapy, compared with any other treatment, for adults with chronic rhinosinusitis.
DATA SOURCES
EMBASE and PubMed databases were searched in October 2011.
REVIEW METHODS
A total of 1216 citations were screened initially by a single author, 23 full-text manuscripts were evaluated by 2 authors using structured data abstraction forms to assess for inclusion criteria and study quality, and 3 studies were included in the final review.
RESULTS
This review finds that 3 prospective clinical studies have evaluated the effect of macrolide therapy for chronic rhinosinusitis. Based on the limited data, there is limited scientific evidence to support the use of long-term macrolide therapy for chronic rhinosinusitis.
CONCLUSION
Further clinical research is needed to determine whether there may be a subgroup effect based on the underlying inflammatory disease process.
摘要
目的
本研究旨在系统评价与其他治疗方法相比，长期大环内酯治疗成人慢性鼻-鼻窦炎的患者报告结局。
资料来源
2011 年 10 月检索了 EMBASE 和 PubMed 数据库。
研究方法
最初由一名作者筛选了 1216 条引文，两名作者使用结构化数据提取表评估了 23 篇全文文献，以评估纳入标准和研究质量，并最终纳入了 3 项研究进行综述。
结果
本综述发现，有 3 项前瞻性临床研究评估了大环内酯治疗慢性鼻-鼻窦炎的效果。基于有限的数据，目前仅有有限的科学证据支持长期大环内酯治疗慢性鼻-鼻窦炎。
结论
需要进一步的临床研究来确定是否基于潜在的炎症疾病过程存在亚组效应。
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