Barker D J, Coggon D, Osmond C, Wickham C
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.
Br J Cancer. 1990 Apr;61(4):575-8. doi: 10.1038/bjc.1990.129.
In a search for aetiological processes which might explain the association of stomach cancer with poverty, we have related mortality from the disease in the local authority areas of England and Wales during 1968-78 to indices of living standards derived from the 1971, 1951 and 1931 censuses. We have also analysed recently released data from a national survey of overcrowding carried out in 1936. Geographical differences in stomach cancer were most closely related to occupationally derived indices of socio-economic structure from the 1971 census, and to measures of domestic crowding from the 1931 census and 1936 survey. Unlike other indices of poor living standards, levels of past domestic crowding in north-west Wales were consistent with its previously unexplained high death rates from stomach cancer. We conclude that overcrowding in the home during childhood may be a major determinant of stomach cancer, and might act by promoting the transmission of causative organisms.
为探寻可能解释胃癌与贫困之间关联的病因学过程，我们将1968 - 1978年间英格兰和威尔士地方政府辖区内该疾病的死亡率与源自1971年、1951年和1931年人口普查的生活水平指标相关联。我们还分析了最近公布的1936年全国过度拥挤情况调查的数据。胃癌的地理差异与1971年人口普查中职业衍生的社会经济结构指标，以及1931年人口普查和1936年调查中的家庭拥挤程度测量最为密切相关。与其他贫困生活水平指标不同，威尔士西北部过去的家庭拥挤程度与该地区此前无法解释的高胃癌死亡率相符。我们得出结论，儿童时期家庭过度拥挤可能是胃癌的一个主要决定因素，并且可能通过促进致病生物的传播而起作用。
