Coggon D, Osmond C, Barker D J
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.
Br J Cancer. 1990 Apr;61(4):573-4. doi: 10.1038/bjc.1990.128.
Rates of stomach cancer vary from place to place within England and Wales. To determine whether this reflects influences acting earlier or later in life, we have analysed mortality from the disease by county of birth and county of death. Among 749,035 men and women who died during 1969-72 in a different county from that in which they were born, proportional mortality from stomach cancer was more closely related to county of birth than of death. This association with place of birth was found in migrants both out of and into high-risk areas. We conclude that studies seeking to explain local differences in the incidence of stomach cancer within England and Wales should focus on the environment of patients in their youth.
在英格兰和威尔士，胃癌发病率因地区而异。为了确定这是否反映了生命早期或晚期所受的影响，我们按出生郡和死亡郡分析了该疾病的死亡率。在1969年至1972年间死于与出生郡不同的郡的749,035名男性和女性中，胃癌的比例死亡率与出生郡的关联比与死亡郡的更为密切。这种与出生地的关联在进出高风险地区的移民中均有发现。我们得出结论，旨在解释英格兰和威尔士胃癌发病率地区差异的研究应关注患者年轻时的环境。
