Berenguer Alberto, Couto Alexandra, Brites Vera, Fernandes Rosário
Department of Pediatrics, Central Hospital of Funchal, Portugal.
BMJ Case Rep. 2013 Jan 11;2013:bcr2012007055. doi: 10.1136/bcr-2012-007055.
Anaphylaxis is a rare condition in pregnancy. Drugs are the aetiological agents most often implicated. Maternal anaphylaxis can lead to significant fetal morbidity and even mortality if uterine perfusion and maternal oxygenation are compromised. Significant risk of neonatal neurological damage or death can occur even when the maternal clinical outcome is favourable. The authors present the case of a newborn, born at gestational age of 29 weeks, who died at 11 days of life with hypoxic-ischaemic cerebral injuries as a consequence of maternal anaphylaxis following the administration of amoxicillin in the community setting.
过敏反应在孕期较为罕见。药物是最常涉及的病因。如果子宫灌注和母体氧合受到影响，母体过敏反应可导致严重的胎儿发病甚至死亡。即使母体临床结局良好，新生儿也可能面临显著的神经损伤或死亡风险。作者报告了一例孕29周出生的新生儿病例，该新生儿在出生11天时因在社区环境中使用阿莫西林后发生母体过敏反应而死于缺氧缺血性脑损伤。
