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对于 CD4+T 淋巴细胞计数>=300 个/μL 且 HIV-1 得到抑制的患者，是否需要频繁进行 CD4+T 淋巴细胞计数监测？

Is frequent CD4+ T-lymphocyte count monitoring necessary for persons with counts >=300 cells/μL and HIV-1 suppression?

机构信息

Infectious Diseases Section, Medical Service, Veterans Affairs Medical Center, 50 Irving St NW, Washington, DC 20422, USA.

出版信息

Clin Infect Dis. 2013 May;56(9):1340-3. doi: 10.1093/cid/cit004. Epub 2013 Jan 11.

DOI:10.1093/cid/cit004
PMID:23315315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3693489/
Abstract

Among patients infected with human immunodeficiency virus (HIV), those with HIV-1 RNA <200 copies/mL and CD4 counts ≥300 cells/µL had a 97.1% probability of maintaining durable CD4 ≥200 cells/µL for 4 years. When non-HIV causes of CD4 lymphopenia were excluded, the probability rose to 99.2%. Our data support less frequent CD4 monitoring during viral suppression.

摘要

在感染人类免疫缺陷病毒 (HIV) 的患者中，那些 HIV-1 RNA <200 拷贝/毫升且 CD4 计数≥300 个/微升的患者，有 97.1%的概率在 4 年内维持持久的 CD4 ≥200 个/微升。当排除非 HIV 导致的 CD4 淋巴细胞减少症的原因时，这一概率上升至 99.2%。我们的数据支持在病毒抑制期间减少 CD4 监测的频率。

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