tRNA 修饰：应激恢复过程中正确的 tRNA 衍生片段所必需的吗？

tRNA modifications: necessary for correct tRNA-derived fragments during the recovery from stress?

机构信息

Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.

出版信息

Bioessays. 2013 Apr;35(4):323-7. doi: 10.1002/bies.201200158. Epub 2013 Jan 11.

DOI:10.1002/bies.201200158

Abstract

Endonuclease-mediated tRNA fragmentation has been observed in many species suggesting functional importance for tRNA fragments. The size distribution of tRNA-derived fragments indicates the existence of mechanisms that protect tRNAs and their fragments from total degradation by exonucleases. Could post-transcriptional modifications be important for the controlled processing of tRNAs?

摘要

内切核酸酶介导的 tRNA 片段化在许多物种中都有观察到，这表明 tRNA 片段具有重要的功能。tRNA 衍生片段的大小分布表明存在一些机制，可以保护 tRNA 及其片段不被外切核酸酶完全降解。转录后修饰对于 tRNA 的可控加工是否重要？