Pandey Kush Kumar, Madhry Deeksha, Ravi Kumar Y S, Malvankar Shivani, Sapra Leena, Srivastava Rupesh K, Bhattacharyya Sankar, Verma Bhupendra
Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Department of Biotechnology, M.S. Ramaiah, Institute of Technology, MSR Nagar, Bengaluru, India.
Mol Ther Nucleic Acids. 2021 Jul 2;26:161-173. doi: 10.1016/j.omtn.2021.06.023. eCollection 2021 Dec 3.
Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases.
人类基因组编码了数百个tRNA基因和假基因。tRNA是细胞中第二丰富的RNA类型。深度测序技术的进步揭示了功能性tRNA衍生RNA片段（tRFs）的大量表达。它们要么从前体（pre-）tRNA产生，要么从成熟tRNA产生。已发现它们在不同病理条件下发挥关键的调节作用。在此，我们简要总结了tRFs在不同人类疾病病理生理学中调节作用的发现和最新进展。
