Graduate Division of Biological and Biomedical Sciences, Nutrition and Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA 30322, USA.
Ann N Y Acad Sci. 2013 Apr;1281(1):51-63. doi: 10.1111/j.1749-6632.2012.06838.x. Epub 2013 Jan 14.
Type 2 diabetes mellitus (T2DM) is one of the leading causes of morbidity and mortality. While all ethnic groups are affected, the prevalence of T2DM in South Asians, both in their home countries and abroad, is extremely high and is continuing to rise rapidly. Innate biological susceptibilities coupled with rapid changes in physical activity, diet, and other lifestyle behaviors are contributing factors propelling the increased burden of disease in this population. The large scope of this problem calls for investigations into the cause of increased susceptibility and preventative efforts at both the individual and population level that are aggressive, culturally sensitive, and start early. In this review, we outline the biological and environmental factors that place South Asians at elevated risk for T2DM, compared with Caucasian and other ethnic groups.
2 型糖尿病（T2DM）是发病率和死亡率的主要原因之一。虽然所有种族都受到影响，但南亚裔人群在其国内和国外的 T2DM 患病率极高，且呈快速上升趋势。先天的生物易感性，加上身体活动、饮食和其他生活方式行为的迅速变化，是导致该人群疾病负担增加的因素。这个问题的范围很广，需要研究增加易感性的原因，并在个人和人群层面采取积极、文化敏感和早期的预防措施。在这篇综述中，我们概述了与白种人和其他种族相比，使南亚裔人群面临更高的 T2DM 风险的生物和环境因素。
