血管内皮生长因子和 p53 在退变椎间盘组织中的表达及意义。
Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue.
机构信息
Rehabilitation Medicine, Hospital of Special Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong Province, China 510010.
出版信息
Asian Pac J Trop Med. 2013 Jan;6(1):79-81. doi: 10.1016/S1995-7645(12)60206-5.
OBJECTIVE
To investigate the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.
METHODS
Pathological sections collected from 156 patients with lumbar disc herniation after surgery were tested by immunohistochemistry method, for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.
RESULTS
98 cases (62.8%) with vascular infiltration phenomenon are found, and positive rates of VEGF and p53 in degenerate intervertebral disc tissue are 73.42% (116/156) and 58.97% (92/156); co-expression rate is 53.2%(83/156); the expression rates of VEFG and p53 are significantly higher in the tissue with blood vessel infiltration than in the tissue without infiltration; there is a close relationship of VEGF with p53.
CONCLUSIONS
VEGF and p53 gene synergetic express in degenerate intervertebral disc tissue, working together in neovascularization and infiltration, and accelerating intervertebral disc tissue degeneration.
目的
研究血管内皮生长因子（VEGF）和 p53 在退变椎间盘组织中的表达机制及其意义。
方法
对 156 例腰椎间盘突出症患者术后病理切片进行免疫组化检测，评估 VEGF 和 p53 在退变椎间盘组织中的表达。
结果
发现 98 例（62.8%）有血管浸润现象，退变椎间盘组织中 VEGF 和 p53 的阳性率分别为 73.42%（116/156）和 58.97%（92/156）；共表达率为 53.2%（83/156）；有血管浸润的组织中 VEGF 和 p53 的表达率明显高于无血管浸润的组织；VEGF 与 p53 密切相关。
结论
VEGF 和 p53 基因在退变椎间盘组织中协同表达，共同参与新生血管形成和浸润，加速椎间盘组织退变。
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