Carrillo-Muñoz Alfonso Javier, Tur-Tur Cristina, Cárdenes Délia, Rojas Florencia, Giusiano Gustavo
Alfonso Javier Carrillo-Muñoz. Apdo. Postal 10178. E-08080 Barcelona. Spain.
Rev Esp Quimioter. 2015 Aug;28(4):210-3.
We studied the in vitro antifungal activity profile of amorolfine (AMR), bifonazole (BFZ), clotrimazole (CLZ), econazole (ECZ), fluconazole (FNZ), itraconazole (ITZ), ketoconazole (KTZ), miconazole (MNZ), oxiconazole (OXZ), tioconazole (TCZ) and terbinafine (TRB) against 26 clinical isolates of Scopulariopsis brevicaulis from patients with onychomycosis by means of an standardized microdilution method. Although this opportunistic filamentous fungi was reported as resistant to several broad-spectrum antifungals agents, obtained data shows a better fungistatic in vitro activity of AMR, OXZ and TRB (0.08, 0.3, and 0.35 mg/L, respectively) in comparison to that of CLZ (0.47 mg/L), ECZ (1.48 mg/L), MNZ (1.56 mg/L, BFZ (2.8 mg/L), TCZ (3.33 mg/L), KTZ (3.73 mg/L). FNZ (178.47 mg/L) and ITZ (4.7 mg/L) showed a reduced in vitro antifungal activity against S. brevicaulis. Obtained MICs show the low in vitro antifungal susceptibility of S. brevicaulis to topical drugs for onychomycosis management, with exceptions (AMR, OZX and TRB).
我们采用标准化微量稀释法，研究了阿莫罗芬（AMR）、联苯苄唑（BFZ）、克霉唑（CLZ）、益康唑（ECZ）、氟康唑（FNZ）、伊曲康唑（ITZ）、酮康唑（KTZ）、咪康唑（MNZ）、奥昔康唑（OXZ）、噻康唑（TCZ）和特比萘芬（TRB）对26株来自甲癣患者的短帚霉临床分离株的体外抗真菌活性谱。尽管这种机会性丝状真菌被报道对几种广谱抗真菌药物耐药，但获得的数据显示，与CLZ（0.47mg/L）、ECZ（1.48mg/L）、MNZ（1.56mg/L）、BFZ（2.8mg/L）、TCZ（3.33mg/L）、KTZ（3.73mg/L）相比，AMR、OXZ和TRB（分别为0.08、0.3和0.35mg/L）具有更好的体外抑菌活性。FNZ（178.47mg/L）和ITZ（4.7mg/L）对短帚霉的体外抗真菌活性降低。获得的最低抑菌浓度显示，除了AMR、OZX和TRB外，短帚霉对用于甲癣治疗的局部药物的体外抗真菌敏感性较低。
