Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Acta Trop. 2013 Apr;126(1):37-42. doi: 10.1016/j.actatropica.2013.01.002. Epub 2013 Jan 11.
There have been few studies on human trichostrongyliasis in Southeast Asia, information on its clinical manifestations is also sparse. Trichostrongyliasis occurs predominantly in areas where poor hygiene is common especially where human/animal feces are used as a fertilizer, thereby contaminating vegetables and stream water. The intimate coexistence of domestic animals and humans explains the prevalence of Trichostrongylus infection in such areas. The goal of the current study was to determine the prevalence of trichostrongyliasis among villagers in Thakamrien village, Sonkon district, Savannakhet province, Laos, and to investigate potential relationships between clinical features, laboratory data, and severity of infection. Of 272 villagers examined, 160 (58.8%) were determined positive for helminthic infections by fecal examination, and 59 (36.9%) of these were infected with Trichostrongylus. Only 58 cases were in the inclusion criteria of the study and then underwent further assessment, including a questionnaire on personal behaviors, physical examination, and laboratory tests. Villagers in the trichostrongyliasis group were more likely than the control group to have consumed fresh vegetables, not washed their hands before meals or after using the toilet, and to have had close contact with herbivorous animals (goats and cows). Similarly, villagers in the trichostrongyliasis group were more likely than the control group to have a history of loose feces, rash, or abdominal pain; however, no obvious clinical symptoms were observed during physical examination of the trichostrongyliasis patients. The degree of infection was determined by both fecal egg counts and quantification of adult worms after deworming. Laboratory data were evaluated for any relationship with severity of infection. No significant differences were found in laboratory values between the trichostrongyliasis and control groups, with most values being within normal limits; however, both groups had high eosinophil counts. This study demonstrated that the useful clinical characteristics of trichostrongyliasis patients include history of loose feces, rashes, and abdominal pain, as well as in personal behaviors, such as the regular consumption of fresh vegetables, lack of hand washing, and close contact with cattle.
在东南亚，关于人类类圆线虫病的研究很少，其临床表现的信息也很匮乏。类圆线虫病主要发生在卫生条件差的地区，特别是在人类/动物粪便被用作肥料的地区，从而污染了蔬菜和溪流的水。家养动物和人类的密切共存解释了这些地区旋毛虫感染的流行。本研究的目的是确定老挝沙拉湾省松孔凯区塔卡米伦村村民类圆线虫病的流行情况，并调查临床特征、实验室数据和感染严重程度之间的潜在关系。在接受检查的 272 名村民中，通过粪便检查确定 160 名（58.8%）患有寄生虫感染，其中 59 名（36.9%）感染了类圆线虫。只有 58 例符合研究纳入标准，并进一步进行了评估，包括个人行为、体检和实验室检查的问卷。类圆线虫病组的村民比对照组更有可能食用新鲜蔬菜、饭前或便后不洗手、与食草动物（山羊和牛）密切接触。同样，类圆线虫病组的村民比对照组更有可能有稀便、皮疹或腹痛的病史；然而，在对类圆线虫病患者进行体检时，没有观察到明显的临床症状。感染程度是通过粪便虫卵计数和驱虫后成虫定量来确定的。评估了实验室数据与感染严重程度的关系。在类圆线虫病组和对照组之间，实验室值没有发现显著差异，大多数值在正常范围内；然而，两组的嗜酸性粒细胞计数都很高。本研究表明，类圆线虫病患者有用的临床特征包括稀便、皮疹和腹痛病史，以及个人行为，如经常食用新鲜蔬菜、缺乏洗手和与牛密切接触。
