钯（II）催化的吡咯烷衍生物的对映选择性和非对映选择性合成。
Palladium(II)-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives.
机构信息
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.
出版信息
Org Lett. 2012 Aug 17;14(16):4074-7. doi: 10.1021/ol3016989. Epub 2012 Aug 8.
Abstract
A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity.
摘要
钯催化的吡咯烷衍生物的对映选择性和非对映选择性合成被描述。初始的分子内亲核钯化连接的保护胺形成吡咯烷部分和醌甲醚中间体。第二个亲核试剂进行分子间加成，以高对映选择性和非对映选择性得到各种产物。
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