Thermoresponsive hydrogels for cellular delivery.

The delivery of living cells into a host body has emerged as a promising approach to treating a variety of different diseases and for tissue repair. However, one of the major obstacles for clinical success is to deliver the cells to the target tissue without losing control of cell fate and function after transplantation. Temperature-responsive biomaterials represent a promising vehicle to deliver cells noninvasively by injection of a liquid precursor, which undergoes a reversible phase transition at body temperature, thus, forming temperature-induced hydrogels in situ. The final material provides transplanted cells with a synthetic extracellular matrix, which retains the cells at the injection site, supports cell growth and mitigates migration. This mini review is intended to cover the fundamental physicochemical characteristics of these thermoresponsive biomaterials, and to examine the applications, with a focus on the recently developed cell-delivery systems for tissue engineering and cell therapy, including advantages, limitations and future challenges.