[二水焦磷酸钙晶体沉积病：20例临床病理分析]
[Calcium pyrophosphate dihydrate crystal deposition disease: a clinicopathologic analysis of 20 cases].
作者信息
Fang Hui-qiong, Li Qi-ming, Huang Yao-qu, Xing Ji-si, Mao Rong-jun, Xie Le
机构信息
Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China.
出版信息
Zhonghua Bing Li Xue Za Zhi. 2012 Dec;41(12):828-32. doi: 10.3760/cma.j.issn.0529-5807.2012.12.008.
OBJECTIVE
To investigate the clinicopathologic features of calcium pyrophosphate dihydrate crystal deposition disease (CPPD-CDD).
METHODS
The clinical and pathologic profiles were retrospectively analysed in 20 cases of CPPD-CDD.
RESULTS
CPPD-CDD was far more common in women, most frequently involving joints, especially the knees and presenting with various arthrisis. Abnormally calcified and the articular damages were characteristic features by imageing. Histologically, multifocal indigo granular calcinosis was seen in synovium and sometimes appeared as needle-shaped or rhomboid crystals, which characterized the CPPD.
CONCLUSIONS
Though clinical symptoms of CPPD are quite variable, the definite diagnosis can be made by the abnormal calcification and joint damage radiographically and the indigo CPPD crystals histopathologically.
目的
探讨二水焦磷酸钙晶体沉积病（CPPD-CDD）的临床病理特征。
方法
回顾性分析20例CPPD-CDD患者的临床和病理资料。
结果
CPPD-CDD在女性中更为常见，最常累及关节，尤其是膝关节，并表现为各种关节炎。影像学上，异常钙化和关节损伤是其特征性表现。组织学上，滑膜可见多灶性蓝色颗粒状钙质沉着，有时呈针状或菱形晶体，这是CPPD的特征。
结论
虽然CPPD的临床症状变化很大，但通过影像学上的异常钙化和关节损伤以及组织病理学上的蓝色CPPD晶体可以做出明确诊断。
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