Balslev E, Thomsen H K, Weismann K
Bispebjerg Hospital, Copenhagen, Denmark.
J Clin Pathol. 1990 Mar;43(3):201-2. doi: 10.1136/jcp.43.3.201.
Acute exanthema occurs in patients who are human immunodeficiency virus (HIV) positive before they become seropositive. The patients have influenza like symptoms and a macular skin rash on the upper trunk. Histopathological investigation of skin punch biopsy specimens from four patients with acute HIV exanthema showed a normal epidermis and a sparse dermal, mainly perivascular, lymphocytic/histiocytic infiltrate around vessels of the superficial plexus. Histopathological changes of the exanthema of acute HIV infection are non-specific and resemble those of other acute viral exanthema, but when both the histopathological features and the clinical picture are suggestive, the clinician should take into consideration the possibility of HIV infection.
急性疹发生于人类免疫缺陷病毒（HIV）阳性患者在血清学呈阳性之前。患者有流感样症状，上躯干出现斑疹。对4例急性HIV疹患者的皮肤打孔活检标本进行组织病理学检查，结果显示表皮正常，真皮层稀疏，主要是血管周围有淋巴细胞/组织细胞浸润，位于浅静脉丛血管周围。急性HIV感染疹的组织病理学变化是非特异性的，与其他急性病毒疹相似，但当组织病理学特征和临床表现都有提示意义时，临床医生应考虑HIV感染的可能性。
