Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature. 2013 Jan 17;493(7432):327-37. doi: 10.1038/nature11860.
Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.
神经元活动诱导突触分子的翻译后修饰，促进树突内局部蛋白质合成，并激活基因转录，从而调节突触功能，使神经元回路能够对经验做出动态响应。有证据表明，自闭症谱系障碍中发生突变的许多基因是调节突触发育和可塑性的活性依赖性信号转导网络的关键组成部分。因此，神经元中活性依赖性信号通路的失调可能在自闭症谱系障碍的发病机制中起关键作用。
