Smith A N, Spencer J A, Stringfellow J S, Vygantas K R, Welch J A
Department of Small Animal Surgery, College of Veterinary Medicine, Auburn University, AL 36849, USA.
J Am Vet Med Assoc. 2000 Mar 1;216(5):708-12, 684-5. doi: 10.2460/javma.2000.216.708.
A 4-year-old spayed female German Shepherd Dog was evaluated because of left forelimb lameness. A fungal granuloma on the distal portion of the radius was determined to be the cause of the lameness; the infecting organism was identified as Phialemonium obovatum. Despite aggressive treatment with amphotericin B, itraconazole, and ketoconazole and curettage of the local area, the dog developed systemic disease and was euthanatized 5 months after initial evaluation. Immune dysfunction may have played a role in development of disseminated disease, because although serum concentrations of total IgG, IgA, and IgM were within or greater than reference ranges, results of lymphocyte proliferation assays were abnormal, which indicated cellular immune dysfunction. Infection with Phialemonium obovatum should be considered as a differential diagnosis when branching fungal organisms are detected during histologic, cytologic, or microbiologic evaluation of tissue specimens.
一只4岁已绝育的雌性德国牧羊犬因左前肢跛行前来就诊。经诊断，桡骨远端的真菌性肉芽肿是导致跛行的原因；感染病原体被鉴定为倒卵形瓶霉。尽管使用两性霉素B、伊曲康唑和酮康唑进行了积极治疗，并对局部进行了刮除术，但这只狗仍发展为全身性疾病，并在初次评估后5个月实施了安乐死。免疫功能障碍可能在播散性疾病的发展中起了作用，因为尽管血清总IgG、IgA和IgM浓度在参考范围内或高于参考范围，但淋巴细胞增殖试验结果异常，表明存在细胞免疫功能障碍。在对组织标本进行组织学、细胞学或微生物学评估时，若检测到分支真菌病原体，应将倒卵形瓶霉感染作为鉴别诊断的考虑因素。
