Yang Jian-Hong, Wang Wei-Guang, Du Xue, He Fei, Zhang Hai-Bo, Li Xiao-Nian, Li Yan, Pu Jian-Xin, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
J Nat Prod. 2014 Nov 26;77(11):2444-53. doi: 10.1021/np5005196. Epub 2014 Nov 6.
Thirteen new heterodimeric ent-kauranoids, bistenuifolins A-M (1-13), were isolated from the aerial parts of Isodon tenuifolius. The constituent units of compounds 1-6 were linked by a six-membered dihydropyran ring, while those of compounds 7-11 were joined by a rare single carbon-carbon bond (C-16→C-17'). The constituent units of 12 and 13 were linked via an unusual cyclobutane moiety. The structures of these metabolites were established via spectrometric analyses, and the absolute configurations of 1 and 4 were defined by single-crystal X-ray diffraction. Selected compounds were evaluated for their cytotoxicity against a small panel of human tumor cell lines; bistenuifolin B (2) exhibited weak inhibitory effects.
从细叶香茶菜的地上部分分离出13种新的异二聚贝壳杉烷型二萜，即双细叶香茶菜素A - M（1 - 13）。化合物1 - 6的组成单元通过一个六元二氢吡喃环相连，而化合物7 - 11的组成单元则通过一个罕见的单碳 - 碳键（C - 16→C - 17'）连接。化合物12和13的组成单元通过一个不寻常的环丁烷部分相连。这些代谢产物的结构通过光谱分析确定，化合物1和4的绝对构型通过单晶X射线衍射确定。对选定的化合物进行了针对一小部分人类肿瘤细胞系的细胞毒性评估；双细叶香茶菜素B（2）表现出微弱的抑制作用。
