Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, PR China.
Neurosci Lett. 2013 Mar 1;536:56-63. doi: 10.1016/j.neulet.2013.01.008. Epub 2013 Jan 14.
Wallerian degeneration (WD) remains a subject of critical research interest in modern neurobiology. WD is a process which a large number of genes are differentially regulated, especially the early response to activate nerve degeneration and regeneration, but the precise mechanisms remain elusive. In this study, we report the signal pathways, key regulate recurrent neural networks and signal flow in the early WD. The data indicated that there are several kinds of up- or down-regulated genes, relating to the regulation of response to stimulus, signal transmission via phosphorylation event, immune response, apoptosis and regulation of cell communication. KEGG pathway analysis revealed activity mainly relating to cytokine-cytokine receptor interaction, MAPK signaling pathway, Jak-STAT signaling pathway, ErbB signaling pathway and TGF-beta signaling pathway involved in the recurrent neural networks that were regulated by the key factors, Cldn-14, Cldn-15, ITG, BID and BIRC3. These results will help to much better understand information relating to the early response to WD and provide us with a firmer basis in future investigations on the molecular mechanisms of WD that regulate nerve degeneration and/or regeneration.
Wallerian 变性（WD）仍然是现代神经生物学中一个备受关注的研究课题。WD 是一个大量基因差异调节的过程，特别是对激活神经变性和再生的早期反应，但确切的机制仍难以捉摸。在这项研究中，我们报告了 WD 早期信号通路、关键调节反复神经网络和信号流。数据表明，存在几种上调或下调的基因，与对刺激的反应调节、通过磷酸化事件的信号转导、免疫反应、细胞凋亡和细胞通讯调节有关。KEGG 通路分析显示，活性主要与细胞因子-细胞因子受体相互作用、MAPK 信号通路、Jak-STAT 信号通路、ErbB 信号通路和 TGF-β信号通路有关，这些通路涉及反复神经网络的调节，受关键因素 Cldn-14、Cldn-15、ITG、BID 和 BIRC3 的调节。这些结果将有助于更好地理解与 WD 早期反应有关的信息，并为我们未来研究 WD 调节神经变性和/或再生的分子机制提供更坚实的基础。
